Certified Clinical Transplant Nurse (CCTN) Practice Exam 2026 - Free CCTN Practice Questions and Study Guide

Epstein-Barr Virus (EBV) is well-known for its role in causing infectious mononucleosis, commonly referred to as "mono." This virus is a member of the herpesvirus family and is particularly significant in the context of organ transplantation. Transplant recipients are at an increased risk for complications associated with EBV due to their immunocompromised status, which can lead to opportunistic infections.

EBV can reactivate in individuals who have been previously infected, especially when they are on immunosuppressive therapy following a transplant. This reactivation can result in the development of post-transplant lymphoproliferative disease (PTLD), a serious complication where lymphocytes (a type of white blood cell) multiply uncontrollably. The managing of EBV infection is crucial in transplant protocols to ensure patient safety and long-term health outcomes.

In contrast, while the other viruses listed are associated with their respective diseases, they do not specifically transmit mononucleosis and pose different risks in the transplant population. For example, Hepatitis B and C primarily affect the liver, and HIV is associated with immunodeficiency and opportunistic infections rather than mononucleosis. Thus, Epstein-Barr Virus is the most relevant choice in